Mouse monoclonal primary
BHMT Mouse Monoclonal Antibody [9E1] (EM1701-64)
Human kidney tissue lysate, human liver tissue, HepG2, SiHa, rat kidney tissue, mouse liver tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G purified.
Betaine homocysteine methyltransferase antibody; Betaine homocysteine S methyltransferase 1 antibody; Betaine homocysteine S methyltransferase antibody; Betaine--homocysteine S-methyltransferase 1 antibody; BHMT antibody; BHMT1 antibody; BHMT1_HUMAN antibody; EC 188.8.131.52 antibody; Epididymis secretory sperm binding protein Li 61p antibody; HEL S 61p antibody
Found exclusively in liver and kidney.
Betaine-homocysteine methyltransferase (BHMT) is a zinc-dependent cytosolic protein that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. BHMT is highly expressed in rat liver, and its expression is regulated by dietary methionine and choline. In humans, S-adenosylmethionine (SAM) down-regulates BHMT expression by inducing NFκB, which acts as a repressor for the BHMT gene. Lowered BHMT levels can lead to ER (endoplasmic reticulum) stress. Mutations in the gene encoding for BHMT may lead to hyperhomocysteinemia, a medical condition characterized by abnormally large amounts of homocysteine in the blood which may be a risk factor for cardiovascular and cerebrovascular diseases.