beta I Tubulin Recombinant Rabbit Monoclonal Antibody [JE01-23] (HA722290)

UNIPROT #

Q9H4B7

PROTEIN NAME

beta I Tubulin

SYNONYMS

2810484G07Rik antibody;beta 1 tubulin antibody;Beta tubulin 1, class VI antibody;Beta-tubulin antibody;Class VI beta tubulin antibody;dJ543J19.4 antibody;M(beta)1 antibody;TBB1_HUMAN antibody;TUBB1 antibody;Tubulin beta 1 class VI antibody;Tubulin beta-1 chain antibody;Tubulin, beta 1 antibody;tubulin, beta1 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton.

FUNCTION

TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.