beta Amyloid 1-42 Recombinant Rabbit Monoclonal Antibody [PSH02-83] (HA721789)
Catalog# HA721789
Rabbit Monoclonal to beta Amyloid 1-42
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WB
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IHC-P
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IF-Tissue
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Human
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Mouse
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Cynomolgus monkey
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Pig
Lane 1: Human Aβ37 full length peptide (negative)
Lane 2: Human Aβ38 full length peptide (negative)
Lane 3: Human Aβ39 full length peptide (negative)
Lane 4: Human Aβ40 full length peptide (negative)
Lane 5: Human Aβ41 full length peptide (negative)
Lane 6: Human Aβ42 full length peptide (positive)
Lane 7: Human Aβ43 full length peptide (negative)
Lane 8: Mouse Aβ42 full length peptide (positive)
Lysates/proteins at 100 ng/Lane.
Predicted band size: 4 kDa
Observed band size: 4 kDa
Exposure time: 59 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA721789) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
beta Amyloid 1-42 Recombinant Rabbit Monoclonal Antibody [PSH02-83] (HA721789)
Immunogen
Synthetic peptide within human beta amyloid 1-42 peptide.
Host
Rabbit
Positive Control
APP/PS1, 6-month mouse of AD brain tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
PSH02-83
RRID
APPLICATION DILUTION
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WB
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1:1,000
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IHC-P
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1:1,000-1:10,000
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IF-Tissue
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1:50
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 4 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
beta Amyloid 1-42
SYNONYMS
A4 antibody;A4_HUMAN antibody;AAA antibody;ABETA antibody;ABPP antibody;AICD-50 antibody;AICD-57 antibody;AICD-59 antibody;AID(50) antibody;AID(57) antibody;AID(59) antibody;Alzheimer disease amyloid protein antibody;Amyloid intracellular domain 50 antibody;Amyloid intracellular domain 57 antibody;Amyloid intracellular domain 59 antibody;APP antibody;APPI antibody;Beta amyloid protein 42 antibody;Beta APP42 antibody;Beta-APP40 antibody;Beta-APP42 antibody;C31 antibody;Cerebral vascular amyloid peptide antibody;CVAP antibody;Gamma-CTF(50) antibody;Gamma-CTF(57) antibody;Gamma-CTF(59) antibody;PN-II antibody;PreA4 antibody;Protease nexin-II antibody;S-APP-alpha antibody;S-APP-beta antibody
SUBCELLULAR LOCATION
Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.
FUNCTION
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
CITATIONS
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Zixiang Li,et al
Avicularin inhibits ferroptosis and improves cognitive impairments in Alzheimer's disease by modulating the NOX4/Nrf2 axis
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WB
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Mouse
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Citation
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