beta Actin Mouse Monoclonal Antibody [B4-B2] (M1210-2)

Apple polyphenol extract alleviates lipid accumulation in free‐fatty‐acid‐exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling

Absence of terminal deoxynucleotidyl transferase expression in T‐ALL/LBL accumulates chromosomal abnormalities to induce drug resistance

The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway

Tao Xu

Disabling phosphorylation at the homer ligand of the metabotropic glutamate receptor 5 alleviates complete Freund's adjuvant-induced inflammatory pain

Lijuan Chen,Yiguo Hu

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma

D Zhou

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

Wenjin Yin;Xueli Zhang; Jinsong Lu

TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer

Zhi-Hu Zhao

Coordinated regulation of IFITM1,2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions

Liang, L., Gu, W., Li, M., Gao, R., Zhang, X., Guo, C., & Mi, S.

The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. Cell death & disease, 12(7), 702.

Yingliang Wu,Di Wang

One-Carbon Metabolism Supports SAdenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

Jianguo Xu,and Hong Tan

Macrophage Polarization in Response to Varying Pore Sizes of 3D Polyurethane Scaffolds

Zhang, J. L., Chen, S. J., Liu, X. Y., Moczek, A. P., & Xu, H. J.

The transcription factor Zfh1 acts as a wing-morph switch in planthoppers

Zhang Bao;Jianying Zhou

Triptolide induces atrophy of myotubes by triggering IRS-1 degradation and activating the FoxO3 pathway. Toxicology in vitro : an international journal published in association with BIBRA, 65, 104793.

Wang, K., Huang, W., Chen, R., Lin, P., Zhang, T., Ni, Y. F., Li, H., Wu, J., Sun, X. X., Geng, J. J., Zhu, Y. M., Nan, G., Zhang, W., Chen, X., Zhu, P., Bian, H., & Chen, Z. N.

Di-methylation of CD147-K234 promotes the progression of NSCLC by enhancing lactate export

Jie Wu ;Ayaz Najafov;Hongguang Xia

Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

Song Kangping,et al

Pulsed electromagnetic fields potentiate bone marrow mesenchymal stem cell chondrogenesis by regulating the Wnt/β-catenin signaling pathway

王迪

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

Wu, Y., Zhang, C., Liu, X., He, Z., Shan, B., Zeng, Q., Zhao, Q., Zhu, H., Liao, H., Cen, X., Xu, X., Zhang, M., Hou, T., Wang, Z., Yan, H., Yang, S., Sun, Y., Chen, Y., Wu, R., Xie, T., … Xia, H.

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation. Nature communications, 12(1), 2346.

Xu, T., Ma, Q., Li, Y., Yu, Q., Pan, P., Zheng, Y., Li, Z., Xiong, X., Hou, T., Yu, B., Liu, H., & Sun, Y.

A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer

ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade

Zhou, J., Wang, Y., Qiu, Y., Wang, Y., Yang, X., Liu, C., Shi, Y., Feng, X., Hou, L., & Liu, J.

Contribution of DEAD-Box RNA Helicase 21 to the Nucleolar Localization of Porcine Circovirus Type 4 Capsid Protein

Li Yiming,et al

Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

Zhang, X., He, Y., Jiang, Y., Bao, Y., Chen, Q., Xie, D., Yu, H., & Wang, X.

TMEM229A suppresses non‑small cell lung cancer progression via inactivating the ERK pathway. Oncology reports, 46(2), 176.

Duan, X., Huang, Y., Chen, X., Wang, W., Chen, J., Li, J., Yang, W., Li, J., Wu, Q., & Wong, J.

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis. Oncogenesis, 10(5), 38.

Liu Chao,et al

hnRNPA0 promotes MYB expression by interacting with enhancer lncRNA MY34UE-AS in human leukemia cells

Apple polyphenol extract improves high-fat diet-induced hepatic steatosis by regulating bile acid synthesis and gut microbiota in C57BL/6 male mice

Qin Liu

The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection.

Gao XK, Sheng ZK, Lu YH, et al

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

Zhi-Nan Chen;Juan Tang

Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3

Tian Rui,et al

TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways

Bai, R., Shi, Z., Li, D., Zhou, D., Ge, W. T., & Zheng, S.

Gene expression profile of human colorectal cancer identified NKTR as a biomarker for liver metastasis

Ma, X., Zhang, M., Yan, R., Wu, H., Yang, B., & Miao, Z.

β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia

Zijun Chen;Yunsen Li

Anti-H1N1 viral activity of three main active ingredients from zedoary oil

Dr Tao Li;Professor Wenjun Yang

Narasin inhibits tumor metastasis and growth of ERα-positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL-6/STAT3 signaling pathways

Shu Zheng

High-throughput proteomics integrated with gene microarray for discovery of colorectal cancer potential biomarkers

Zhenyu Ju & Yu-Sheng Cong

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1a stability

Chen, R., Huang, M., Yang, X., Chen, X. H., Shi, M. Y., Li, Z. F., Chen, Z. N., & Wang, K.

CALR-TLR4 Complex Inhibits Non-Small Cell Lung Cancer Progression by Regulating the Migration and Maturation of Dendritic Cells

Zhou, J., Qiu, Y., Zhu, N., Zhou, L., Dai, B., Feng, X., Hou, L., & Liu, J.

The Nucleolar Localization Signal of Porcine Circovirus Type 4 Capsid Protein Is Essential for Interaction With Serine-48 Residue of Nucleolar Phosphoprotein Nucleophosmin-1

Sergio Grinstein,Elina Ikonen,Paul Saftig,Dante Neculai

Lysosomal integral membrane protein-2 (LIMP-2/ SCARB2) is involved in lysosomal cholesterol export

GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma

Ming Zhang,Liangbiao Chen

Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells.

Deng T, Du L, Ding S, et al

Protein kinase Cdc7 supports viral replication by phosphorylating Avibirnavirus VP3 protein

Qihan Wu;Jiemin Wong

USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment

Chen, X. H., Chen, R., Shi, M. Y., Tian, R. F., Zhang, H., Xin, Z. Q., Chen, Z. N., & Wang, K.

Chimeric antigen receptor T cells targeting CD147 for non-small cell lung cancer therapy

Xu, T., Yu, W., Fang, H., Wang, Z., Chi, Z., Guo, X., Jiang, D., Zhang, K., Chen, S., Li, M., Guo, Y., Zhang, J., Yang, D., Yu, Q., Wang, D., & Zhang, X.

Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice

Ma, X. R., Yang, S. Y., Zheng, S. S., Yan, H. H., Gu, H. M., Wang, F., Wu, Y., Dong, Z. J., Wang, D. X., Wang, Y., Meng, X., Sun, J., Xia, H. G., & Zhao, J. W.

Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway

Song Yanna,et al

Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus

Yu, W., Wang, Z., Yu, X., Zhao, Y., Xie, Z., Zhang, K., Chi, Z., Chen, S., Xu, T., Jiang, D., Guo, X., Li, M., Zhang, J., Fang, H., Yang, D., Guo, Y., Yang, X., Zhang, X., Wu, Y., Yang, W., … Wang, D.

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Jiang, X., Wang, X., Ding, X., Du, M., Li, B., Weng, X., Zhang, J., Li, L., Tian, R., Zhu, Q., Chen, S., Wang, L., Liu, W., Fang, L., Neculai, D., & Sun, Q.

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. The EMBO journal, 39(5), e102608.

Wu, D., Li, H., Liu, M., Qin, J., & Sun, Y.

The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness

Yang, X., Wei, W., Tan, S., Guo, L., Qiao, S., Yao, B., & Wang, Z.

Identification and verification of HCAR3 and INSL5 as new potential therapeutic targets of colorectal cancer

Jianli Wang,Zhijian Cai

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.

Zhou, L., Zhang, L., Chen, S., Sun, D., & Qu, J.

Elevated Neddylation Pathway Promotes Th2 Cells Infiltration by Transactivating STAT5A in Hepatocellular Carcinoma

Conjugated linoleic acids inhibit lipid deposition in subcutaneous adipose tissue and alter lipid profiles in serum of pigs

Xue Zhang;Kejing Ying

A novel cell-based assay for dynamically detecting neutrophil extracellular trapsinduced lung epithelial injuries

Liu Li,et al

Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation

Min Xu; Yijin Gao; Yanxin Li

The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient

Zhai, Y., Lin, P., Feng, Z., Lu, H., Han, Q., Chen, J., Zhang, Y., He, Q., Nan, G., Luo, X., Wang, B., Feng, F., Liu, F., Chen, Z., & Zhu, P.

TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes

Lu Py,et al

Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice

Zhi-Gang Zhang

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Hu, J., Huang, Z., Yu, M., Zhang, P., Xia, Z., & Gao, C.

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4+ effector memory T cells

Qin Liu

Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and StressActivated Protein Kinase 1-Dependent Manner

Wang, L., Lv, Q., Wu, P., Luo, S., Liu, S., Chen, X., & Luo, X.

RNA-seq and ATAC-seq analysis of CD163+ macrophage-induced progestin-insensitive endometrial cancer cells

Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10

Dr Xia Liu,Professor Jianchao Wang

Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway

Zhou, J., Qiu, Y., Zhao, J., Wang, Y., Zhu, N., Wang, D., Cui, Y., Guo, J., Sun, T., Ji, Y., Wu, Z., Zeng, P., Li, J., Feng, X., Hou, L., & Liu, J.

The Network of Interactions between the Porcine Epidemic Diarrhea Virus Nucleocapsid and Host Cellular Proteins

You, D., Du, D., Zhao, X., Li, X., Ying, M., & Hu, X.

Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 33(3), 308–322.

Chen, Z., Zhang, Y., Guan, Q., Zhang, H., Luo, J., Li, J., Wei, W., Xu, X., Liao, L., Wong, J., & Li, J.

Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z

SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation

Gao, X. K., Rao, X. S., Cong, X. X., Sheng, Z. K., Sun, Y. T., Xu, S. B., Wang, J. F., Liang, Y. H., Lu, L. R., Ouyang, H., Ge, H., Guo, J. S., Wu, H. J., Sun, Q. M., Wu, H. B., Bao, Z., Zheng, L. L., & Zhou, Y. T.

Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

Zhi‐Nan Chen

Basolateral CD147 induces hepatocyte polarity loss by E‐cadherin ubiquitination and degradation in hepatocellular carcinoma progress

Control of SOX2 protein stability and tumorigenic activity by E3 ligase CHIP in esophageal cancer cells

Zhou, J., Li, J., Li, H., Zhang, Y., Dong, W., Jin, Y., Yan, Y., Gu, J., & Zhou, J.

The serine-48 residue of nucleolar phosphoprotein nucleophosmin-1 plays critical role in subcellular localization and interaction with porcine circovirus type 3 capsid protein. Veterinary research, 52(1), 4.

Bo Zhang,Qiuheng Jin,Lizhen Xu, Ningning Li

Cooperative transport mechanism of human monocarboxylate transporter 2

Shao, R., Wang, X., Xu, T., Xia, Y., & Cui, D.

The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

Jinyan Gu; Jiyong Zhou

Nucleolar protein NPM1 is essential for circovirus replication by binding to viral capsid

Juan Tang;Zhi-Nan Chen

Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer

Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis

Yang D; Liu Q.

Edwardsiella piscicida T3SS effector EseK inhibits MAPKs phosphorylation and promotes bacterial colonization in zebrafish larvae.

Cao Min,et al

Network pharmacology analysis and molecular mechanism of paeoniflorin and its metabolite in prolactinoma cells

Gregory D. Fairn,Brian Raught, Qiming Sun,Dante Neculai

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

Changqing Yang

Telocytes in liver regeneration: possible roles

Gong, H., Gong, T., Liu, Y., Wang, Y., & Wang, X.

Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m6A-YTHDF1-dependent manner

Duan Chunyan,et al

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Guo, Y., Liu, Y., Zhao, S., Xu, W., Li, Y., Zhao, P., Wang, D., Cheng, H., Ke, Y., & Zhang, X.

Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

Wang Jianfeng,et al

Cigarette smoking inhibits myoblast regeneration by promoting proteasomal degradation of NPAT protein and hindering cell cycle progression

Wu, Y., Shen, S., Chen, J., Ni, W., Wang, Q., Zhou, H., Chen, J., Zhang, H., Mei, Z., Sun, X., Shen, P., Jie, Z., Xu, W., Hong, Z., Ma, Y., Wang, K., Wan, S., Wu, H., Xie, Z., Qin, A., … Fan, S.

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis

Hui Li

Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling

Hui Li,Bin-Bing S. Zhou

HPRT1 activity loss is associated with resistance to thiopurine in ALL

Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Rong Zhang g,Jun Li e, Dong Zhou

S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma

Gao, Y., Xiang, D., Li, W., Zheng, X., Wang, L., Li, Z., & Chen, T.

BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT

Wang, L., Yu, P., Wang, J., Xu, G., Wang, T., Feng, J., Bei, Y., Xu, J., Wang, H., Das, S., & Xiao, J.

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N6-Methyladenosine-Modified Yap Expression

Li Yantao,et al

Bovine lactoferrin inhibits inflammatory response and apoptosis in lipopolysaccharide-induced acute lung injury by targeting the PPAR-γ pathway

Integrating network pharmacology and in vivo experimental validation to reveal the alleviation of mailuoning oral liquid on non-alcoholic fatty liver disease

He Ying,et al

ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling

Jiwen Li & JieminWong

Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells

Shuhong Shen,Yanxin Li

A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis