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Beta-2 Microglobulin Rabbit Polyclonal Antibody (0808-2)

Price: Regular price $315.00

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Catalog# 0808-2

Rabbit Polyclonal to Beta-2 Microglobulin

Tested for

  • WB

  • IHC-P

  • FC

Reacts with

  • Human

Specifications

Product Type

Rabbit polyclonal primary

Product Name

Beta-2 Microglobulin Rabbit Polyclonal Antibody (0808-2)

Immunogen

Synthetic peptide within human beta-2 microglobulin aa 21-70.

Host

Rabbit

Positive Control

HL-60 cells.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3068681

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:200

  • FC

  • 1:50

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

13 kDa

Isotype

IgG

TARGET

UNIPROT #

P61769

PROTEIN NAME

Beta-2 Microglobulin

SYNONYMS

B2M antibody;B2MG_HUMAN antibody;Beta 2 microglobin antibody;Beta 2 microglobulin antibody;Beta 2 microglobulin precursor antibody;Beta chain of mhc class 1 proteins antibody;Beta chain of MHC class I molecules antibody;Beta-2-microglobulin form pI 5.3 antibody;CDABP0092 antibody;Hdcma22p antibody

SEQUENCE SIMILARITIES

Belongs to the beta-2-microglobulin family.

POST-TRANSLATIONAL MODIFICATION

Glycation of Ile-21 is observed in long-term hemodialysis patients.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on almost all cells of the body. β-2-Microglobulin associates with the α heavy chain of MHC and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.

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