PRODUCT CODE: 0808-2

Beta-2 Microglobulin Rabbit Polyclonal Antibody (0808-2)

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

Western blot analysis on HL-60 using anti-Beta-2 Microglobulin polyclonal antibody.
  • Western blot analysis on HL-60 using anti-Beta-2 Microglobulin polyclonal antibody.
Western blot analysis on HL-60 using anti-Beta-2 Microglobulin polyclonal antibody.

Applications

  • WB

  • IHC-P

  • FC

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Beta-2 Microglobulin Rabbit Polyclonal Antibody (0808-2)

Immunogen

Peptide

Host

Rabbit

Positive Control

HL-60

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

13kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500

TARGET

UNIPROT #

PROTEIN NAME

Beta-2 Microglobulin

SYNONYMS

B2M antibody; B2MG_HUMAN antibody; Beta 2 microglobin antibody; Beta 2 microglobulin antibody; Beta 2 microglobulin precursor antibody; Beta chain of mhc class 1 proteins antibody; Beta chain of MHC class I molecules antibody; Beta-2-microglobulin form pI 5.3 antibody; CDABP0092 antibody; Hdcma22p antibody

SEQUENCE SIMILARITIES

Belongs to the beta-2-microglobulin family.

POST-TRANSLATIONAL MODIFICATION

Glycation of Ile-21 is observed in long-term hemodialysis patients.

SUBCELLULAR LOCATION

Secretory protein

FUNCTION

β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on almost all cells of the body. β-2-Microglobulin associates with the α heavy chain of MHC and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.