BCL2L15 Rabbit Polyclonal Antibody (ER1901-44)

UNIPROT #

Q5TBC7

PROTEIN NAME

BCL2L15

SYNONYMS

AC124698.1 antibody;B2L15_HUMAN antibody;Bcl-2-like protein 15 antibody;Bcl2-L-15 antibody;BCL2-like 15 antibody;Bcl2l15 antibody;Bfk antibody;C1orf178 antibody;FLJ22588 antibody;Gm566 antibody;Pro apoptotic Bcl 2 protein antibody

SUBCELLULAR LOCATION

Cytosol, nucleus.

FUNCTION

Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.