Rabbit polyclonal primary
BCL2L15 Rabbit Polyclonal Antibody (ER1901-44)
Recombinant protein within human bcl2l15 aa 1-163 / 163.
Rat cecum tissue lysates, human small intestine tissue lysates, A549, MCF-7, SKOV-3, rat large intestine tissue, mouse large intestine tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Predicted band size 18 kDa.
AC124698.1 antibody; B2L15_HUMAN antibody; Bcl-2-like protein 15 antibody; Bcl2-L-15 antibody; BCL2-like 15 antibody; Bcl2l15 antibody; Bfk antibody; C1orf178 antibody; FLJ22588 antibody; Gm566 antibody; Pro apoptotic Bcl 2 protein antibody
Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains a BH2 and BH3 region but not BH1 or BH4. Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic. Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function. Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins. Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.