BCL2L1 Rabbit Polyclonal Antibody (R1308-16)

UNIPROT #

Q07817

PROTEIN NAME

BCL2L1

SYNONYMS

Apoptosis regulator Bcl X antibody;Apoptosis regulator Bcl-X antibody;Apoptosis regulator BclX antibody;B cell lymphoma 2 like antibody;B2CL1_HUMAN antibody;Bcl 2 like 1 protein antibody;Bcl X antibody;Bcl xL antibody;BCL XL/S antibody;Bcl xS antibody;Bcl-2-like protein 1 antibody;Bcl2 Like 1 antibody;Bcl2 related gene antibody;Bcl2-L-1 antibody;BCL2L antibody;Bcl2l1 antibody;BCLX antibody;BclXL antibody;BclXs antibody;DKFZp781P2092 antibody;PPP1R52 antibody;Protein phosphatase 1 regulatory subunit 52 antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

POST-TRANSLATIONAL MODIFICATION

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.; Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.; Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.

SUBCELLULAR LOCATION

Mitochondrion membrane, nucleus membrane, cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Nucleus, Synapse.

FUNCTION

Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis. Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2. It appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.