Bcl2-L-13 Rabbit Polyclonal Antibody (HA500329)

UNIPROT #

Q9BXK5

PROTEIN NAME

Bcl2-L-13

SYNONYMS

Apoptosis facilitator antibody;B2L13_HUMAN antibody;Bcl 2 like 13 antibody;Bcl 2 like 13 protein antibody;Bcl rambo antibody;Bcl-2-like protein 13 antibody;Bcl-rambo antibody;BCL2 like 13 apoptosis facilitator antibody;BCL2 like 13 antibody;Bcl2 like 13 protein antibody;Bcl2-L-13 antibody;BCL2L13 antibody;MIL 1 antibody;MIL1 antibody;MIL1 protein antibody;Protein Mil1 antibody

SUBCELLULAR LOCATION

Mitochondrion membrane, Nucleus.

FUNCTION

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.