Bag1 Rabbit Polyclonal Antibody (R1310-7)

UNIPROT #

Q99933

PROTEIN NAME

Bag1

SYNONYMS

Bag 1 antibody;BAG family molecular chaperone regulator 1 antibody;BAG-1 antibody;BAG1 antibody;BAG1_HUMAN antibody;BCL 2 Associated Athanogene 1 antibody;BCL 2 associated athanogene antibody;BCL 2 binding athanogene 1 antibody;Bcl-2-associated athanogene 1 antibody;BCL2 associated athanogene 1 antibody;BCL2 associated athanogene antibody;Glucocorticoid receptor-associated protein RAP46 antibody;HAP1 antibody;Haptoglobin antibody;RAP 46 antibody;RAP46 antibody

TISSUE SPECIFICITY

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus

FUNCTION

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.