Rabbit polyclonal primary
Bag1 Rabbit Polyclonal Antibody (R1310-7)
Recombinant protein within human bag1 full sequence.
Hela, SW480, F9, HCT116, HT-29, HepG2, 293, 293T, A431
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
35, 38 kDa
Bag 1 antibody; BAG family molecular chaperone regulator 1 antibody; BAG-1 antibody; BAG1 antibody; BAG1_HUMAN antibody; BCL 2 Associated Athanogene 1 antibody; BCL 2 associated athanogene antibody; BCL 2 binding athanogene 1 antibody; Bcl-2-associated athanogene 1 antibody; BCL2 associated athanogene 1 antibody; BCL2 associated athanogene antibody; Glucocorticoid receptor-associated protein RAP46 antibody; HAP1 antibody; Haptoglobin antibody; RAP 46 antibody; RAP46 antibody
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.