Rabbit polyclonal primary
B7-H4(VTCN1) Rabbit Polyclonal Antibody (ER1802-56)
Recombinant protein within human b7-h4 aa 25-259.
SKBR3 cell and human colon tissue lysates, MCF-7, rat epididymid tissue, human breast tissue, human breast tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
31/21/10 kDa (Predicted band size)
B7 family member, H4 antibody; B7 H4 antibody; B7 homolog 4 antibody; B7 superfamily member 1 antibody; B7 superfamily, member 1 antibody; B7-H4 antibody; B7h.5 antibody; B7h4 antibody; B7S1 antibody; B7x antibody; BC032925 antibody; Immune costimulatory protein B7-H4 antibody; Immune costimulatory protein B7H4 antibody; MGC41287 antibody; PRO1291 antibody; Protein B7S1 antibody; RP11 229A19.4 antibody; T cell costimulatory molecule B7x antibody; T-cell costimulatory molecule B7x antibody; V set domain-containing T cell activation inhibitor 1 antibody; V-set domain-containing T-cell activation inhibitor 1 antibody; VCTN1 antibody; Vtcn1 antibody; VTCN1_HUMAN antibody
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.