B3GAT1 Rabbit Polyclonal Antibody (ER1901-15)

UNIPROT #

Q9P2W7

PROTEIN NAME

B3GAT1

SYNONYMS

3-glucuronyltransferase 1 antibody;3-glucuronyltransferase antibody;B3GA1_HUMAN antibody;B3gat1 antibody;Beta 1 3 glucuronyltransferase 1 antibody;Beta-1 antibody;Beta-1,3-glucuronyltransferase 1 antibody;CD 57 antibody;CD57 antibody;CD57 antigen antibody;Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1 antibody;Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 antibody;GlcAT P antibody;GlcAT-P antibody;GLCATP antibody;GlcUAT P antibody;GlcUAT-P antibody;GlcUATP antibody;Glucuronosyltransferase P antibody;HNK 1 antibody;HNK1 antibody;LEU 7 antibody;LEU7 antibody;LEU7 antigen antibody;NK 1 antibody;NK1 antibody;UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase antibody;UDP-GlcUA:glycoprotein beta-1 antibody

SEQUENCE SIMILARITIES

Belongs to the glycosyltransferase 43 family.

TISSUE SPECIFICITY

Mainly expressed in the brain.

POST-TRANSLATIONAL MODIFICATION

The soluble form derives from the membrane form by proteolytic processing.

SUBCELLULAR LOCATION

Golgi apparatus. Secreted. Endoplasmic reticulum.

FUNCTION

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system. The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. Neoplastic CD57 positive cells are seen in conditions as varied as large granular lymphocytic leukaemia, small-cell carcinoma, thyroid carcinoma, and neural and carcinoid tumours. Although the antigen is particularly common in carcinoid tumours, it is found in such a wide range of other conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin and NSE.