AVPR1A Rabbit Polyclonal Antibody (HA500002)

UNIPROT #

P37288

PROTEIN NAME

AVPR1A

SYNONYMS

Antidiuretic hormone receptor 1a antibody;Arginine vasopressin receptor 1A antibody;AVPR 1 antibody;AVPR 1A antibody;AVPR V1a antibody;AVPR1 antibody;AVPR1A antibody;SCCL vasopressin subtype 1a receptor antibody;V1 vascular vasopressin receptor AVPR1A antibody;V1a vasopressin receptor antibody;V1aR antibody;V1AR_HUMAN antibody;Vascular/hepatic type arginine vasopressin receptor antibody;Vascular/hepatic-type arginine vasopressin receptor antibody;Vasopressin V1a receptor antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Human AVPR1A cDNA is 1472 bp long and encodes a 418 amino-acid long polypeptide which shares 72%, 36%, 37%, and 45% sequence identity with rat Avpr1a, human AVPR2, rat Avpr2, and human oxytocin receptor (OXTR), respectively. AVPR1A is a G-protein coupled receptor (GPCR) with 7 transmembrane domains that couples to Gaq/11 GTP binding proteins, which along with Gbl, activate phospholipase C activity.[5][6] Clinically, the V1A receptor is related to vasoconstriction compared to the V1B receptor that is more related to ACTH release or the V2 receptor that is linked to the diuretic function of ADH.