ATR Rabbit Polyclonal Antibody (HA500176)
Catalog# HA500176
Rabbit Polyclonal to ATR
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WB
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IHC-P
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Human
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
ATR Rabbit Polyclonal Antibody (HA500176)
Immunogen
Recombinant protein within human aa 1198-1410.
Host
Rabbit
Positive Control
Hela cell lysates, rat large intestine tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 301 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
ATR
SYNONYMS
Ataxia telangiectasia and Rad3 related antibody;Ataxia telangiectasia and Rad3-related protein antibody;ATR antibody;ATR_HUMAN antibody;FCTCS antibody;FRAP Related Protein 1 antibody;FRAP-related protein 1 antibody;FRP1 antibody;MEC1 antibody;MEC1 mitosis entry checkpoint 1 homolog antibody;Protein kinase ATR antibody;RAC3 antibody;Rad3 related protein antibody;SCKL antibody;SCKL1 antibody;Serine/threonine protein kinase ATR antibody;Serine/threonine-protein kinase ATR antibody
SUBCELLULAR LOCATION
Nucleus, PML body, Chromosome.
FUNCTION
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
CITATIONS
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Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer
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WB
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Human
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Citation
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Zhu X, Cao L, Liu Y, et al
Genotoxicity of bisphenol AF in rats: Detrimental to male reproductive system and probable stronger micronucleus induction potency than BPA
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IHC
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Rat
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Citation
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