ATPase Inhibitory Factor 1 / IF1 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH16-94] (HA751608)

UNIPROT #

Q9UII2

PROTEIN NAME

ATPase Inhibitory Factor 1 / IF1

SYNONYMS

ATIF1_HUMAN antibody;ATP synthase inhibitor protein antibody;ATPase inhibitor antibody;ATPase inhibitor mitochondrial antibody;ATPase inhibitor protein antibody;ATPase inhibitory factor 1 antibody;ATPI antibody;ATPIF 1 antibody;Atpif1 antibody;ATPIP antibody;IF(1) antibody;IF1 antibody;Inhibitor of F(1)F(o)-ATPase antibody;IP antibody;MGC1167 antibody;MGC8898 antibody;mitochondrial antibody

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene. This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. It prevents ATPase from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation. ATP synthase inhibitor forms a one-to-one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.