ATP1A3 Recombinant Rabbit Monoclonal Antibody [JE35-24] (HA721596)

UNIPROT #

P13637

PROTEIN NAME

ATP1A3

SYNONYMS

AHC2 antibody;Alpha(III) antibody;AT1A3_HUMAN antibody;Atp1a3 antibody;ATPase Na+/K+ transporting alpha 3 polypeptide antibody;DYT 12 antibody;DYT12 antibody;MGC13276 antibody;Na(+)/K(+) ATPase alpha(III) subunit antibody;Na(+)/K(+) ATPase alpha-3 subunit antibody;Na+/K+ ATPase 3 antibody;Na+/K+ ATPase alpha 3 subunit antibody;RDP antibody;Sodium potassium ATPase alpha 3 polypeptide antibody;Sodium pump 3 antibody;Sodium pump subunit alpha-3 antibody;Sodium/potassium transporting ATPase alpha 3 chain antibody;Sodium/potassium-transporting ATPase subunit alpha-3 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Sodium/potassium-transporting ATPase subunit alpha-3 is an enzyme that in humans is encoded by the ATP1A3 gene. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.[6] ATP1A3 is expressed early in human development, likely underlying pathophysiology related to several ATP1A3 related diseases.