ATM Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [SI70-01] (HA750096)

UNIPROT #

Q13315

PROTEIN NAME

ATM

SYNONYMS

A-T mutated antibody;A-T mutated homolog antibody;AT mutated antibody;AT1 antibody;ATA antibody;Ataxia telangiectasia mutated antibody;Ataxia telangiectasia mutated gene antibody;Ataxia telangiectasia mutated homolog (human) antibody;Ataxia telangiectasia mutated homolog antibody;ATC antibody;ATD antibody;ATDC antibody;ATE antibody;ATM antibody;ATM serine/threonine kinase antibody;ATM_HUMAN antibody;DKFZp781A0353 antibody;MGC74674 antibody;OTTHUMP00000232981 antibody;Serine protein kinase ATM antibody;Serine-protein kinase ATM antibody;Serine/threonine-protein kinase ATM antibody;Tefu antibody;TEL1 antibody;TEL1, telomere maintenance 1, homolog antibody;TELO1 antibody;Telomere fusion protein antibody

SEQUENCE SIMILARITIES

Belongs to the PI3/PI4-kinase family. ATM subfamily.

TISSUE SPECIFICITY

Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase. During the late stages of DNA damage response, dephosphorylated following deacetylation by SIRT7, leading to ATM deactivation.; Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP60. Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation.

SUBCELLULAR LOCATION

Nucleus,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome By Similarity.

FUNCTION

The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.