ATG4C Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH05-23] (HA750994)

UNIPROT #

Q96DT6

PROTEIN NAME

ATG4C

SYNONYMS

APG4 autophagy 4 homolog C (S. cerevisiae) antibody;APG4 autophagy 4 homolog C antibody;APG4 C antibody;APG4-C antibody;APG4C antibody;ATG 4C antibody;ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody;ATG4 autophagy related 4 homolog C antibody;Atg4c antibody;ATG4C_HUMAN antibody;AUT (S. cerevisiae) like 1, cysteine endopeptidase antibody;AUT like 1, cysteine endopeptidase (S. cerevisiae) antibody;AUT like 1, cysteine endopeptidase antibody;AUT like 3 cysteine endopeptidase antibody;AUT-like 3 cysteine endopeptidase antibody;AUTL1 antibody;AUTL3 antibody;Autophagin 3 antibody;Autophagin-3 antibody;Autophagy related 4C cysteine peptidase antibody;Autophagy related cysteine endopeptidase 3 antibody;Autophagy related protein 4 homolog C antibody;Autophagy-related cysteine endopeptidase 3 antibody;Autophagy-related protein 4 homolog C antibody;Cysteine protease ATG4C antibody;EC 3.4.22 antibody;FLJ14867 antibody;OTTHUMP00000010715 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy.