ATG4A Rabbit Polyclonal Antibody (ER1901-38)

UNIPROT #

Q8WYN0

PROTEIN NAME

ATG4A

SYNONYMS

AI627006 antibody;APG4 autophagy 4 homolog A antibody;Apg4a antibody;ATG4 autophagy related 4 homolog A (S. cerevisiae) antibody;ATG4 autophagy related 4 homolog A antibody;ATG4A antibody;ATG4A_HUMAN antibody;Atg4al antibody;AUT like 2 cysteine endopeptidase antibody;AUT-like 2 cysteine endopeptidase antibody;Autl2 antibody;Autophagin 2 antibody;Autophagin-2 antibody;Autophagy related 4A cysteine peptidase antibody;Autophagy related cysteine endopeptidase 2 antibody;Autophagy related protein 4 homolog A antibody;Autophagy-related cysteine endopeptidase 2 antibody;Autophagy-related protein 4 homolog A antibody;AV169859 antibody;Cysteine protease ATG4A antibody;hAPG4A antibody;MGC107179 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C54 family.

TISSUE SPECIFICITY

Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.