ATF6 Rabbit Polyclonal Antibody (ER1706-34)

UNIPROT #

P18850

PROTEIN NAME

ATF6

SYNONYMS

Activating transcription factor 6 alpha antibody;Activating transcription factor 6 antibody;ATF 6 antibody;ATF6 alpha antibody;ATF6 antibody;ATF6-alpha antibody;ATF6A antibody;ATF6A_HUMAN antibody;cAMP dependent transcription factor ATF 6 alpha antibody;cAMP-dependent transcription factor ATF-6 alpha antibody;Cyclic AMP dependent transcription factor ATF 6 alpha antibody;DKFZp686P2194 antibody;ESTM49 antibody;FLJ21663 antibody;Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody;Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family. ATF subfamily.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.; N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).; Phosphorylated in vitro by MAPK14/P38MAPK.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane. Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.

FUNCTION

Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.