ASS1 Rabbit Polyclonal Antibody (R1608-5)
Catalog# R1608-5
Rabbit Polyclonal to ASS1
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Mouse
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
ASS1 Rabbit Polyclonal Antibody (R1608-5)
Immunogen
Recombinant protein within human ass1 aa 1-208 / 412.
Host
Rabbit
Positive Control
Hela, MCF-7, A549, NIH-3T3, Jurkat, human liver tissue, human kidney tissue, 2 liver tissue, 2 kidney tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IF-Cell
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1:100-1:500
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IHC-P
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1:50-1:200
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FC
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 47 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
ASS1
SYNONYMS
Argininosuccinate synthase 1 antibody;Argininosuccinate synthase antibody;Argininosuccinate synthetase 1 antibody;ASS antibody;Ass-1 antibody;ass1 antibody;ASSA antibody;ASSY_HUMAN antibody;Citrulline aspartate ligase antibody;Citrulline--aspartate ligase antibody;CTLN1 antibody
SEQUENCE SIMILARITIES
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
TISSUE SPECIFICITY
Expressed in adult liver.
DEVELOPMENTAL STAGE
Expressed in fetal liver and kidney.
POST-TRANSLATIONAL MODIFICATION
Acetylated by CLOCK in a circadian manner which negatively regulates its enzyme activity. Deacetylated by histone deacetylases.
SUBCELLULAR LOCATION
Cytoplasm.
FUNCTION
ASS1, also known as argininosuccinate synthase or citrulline-aspartate ligase, belongs to the argininosuccinate synthase family. ASS1 is an urea cycle enzyme with a tetrameric structure composed of identical subunits. It is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. A deficiency of ASS1 causes citrullinemia (CTLN1), an autosomal recessive disease which is characterized by severe vomiting spells and mental retardation.
CITATIONS
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He, J., Lin, M., Zhang, X., Zhang, R., Tian, T., Zhou, Y., Dong, W., Yang, Y., Sun, X., Dai, Y., Xu, Y., Zhang, Z., Xu, M., Lei, Q. Y., Xu, Y., & Lv, L.
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential
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IHC
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WB
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Human
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Citation
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