Aspartate Aminotransferase Mouse Monoclonal Antibody [A2D7] (EM1901-50)

UNIPROT #

P17174

PROTEIN NAME

Aspartate Aminotransferase

SYNONYMS

AATC_HUMAN antibody;Aspartate aminotransferase 1 antibody;Aspartate aminotransferase antibody;Aspartate aminotransferase cytoplasmic antibody;Aspartate aminotransferase cytosolic antibody;ASTQTL1 antibody;cAspAT antibody;cCAT antibody;cysteine aminotransferase, cytoplasmic antibody;cysteine transaminase, cytoplasmic antibody;cytoplasmic antibody;ec 2.6.1.1 antibody;GIG 18 antibody;GIG18 antibody;Glutamate oxaloacetate transaminase 1 antibody;Glutamate oxaloacetate transaminase soluble antibody;Glutamic oxaloacetic transaminase 1 soluble antibody;GOT 1 antibody;GOT1 antibody;Growth inhibiting protein 18 antibody;SGOT antibody;Transaminase A antibody

SEQUENCE SIMILARITIES

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.