Asparagine synthetase Recombinant Rabbit Monoclonal Antibody [SC67-07] (ET1610-50)

UNIPROT #

P08243

PROTEIN NAME

Asparagine synthetase

SYNONYMS

asnS antibody;ASNS_HUMAN antibody;ASNSD antibody;Asparagine synthetase [glutamine-hydrolyzing] antibody;Asparagine synthetase antibody;Cell cycle control protein TS11 antibody;Glutamine dependent asparagine synthetase 3 antibody;Glutamine dependent asparagine synthetase antibody;Glutamine hydrolyzing antibody;Glutamine-dependent asparagine synthetase antibody;OTTHUMP00000024510 antibody;OTTHUMP00000204938 antibody;OTTHUMP00000204939 antibody;OTTHUMP00000204940 antibody;OTTHUMP00000204941 antibody;OTTHUMP00000204942 antibody;TS11 antibody;TS11 cell cycle control protein antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Asparagine synthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. This amidation reaction is similar to that promoted by glutamine synthetase. The enzyme is ubiquitous in its distribution in mammalian organs, but basal expression is relatively low in tissues other than the exocrine pancreas. Cancerous cells exhibit rapid growth and cell division and subsequently have an increased nutritional need. The particularly low-level expression of asparagine synthetase in primary acute lymphoblastic leukemia (ALL) and numerous ALL cell lines, as compared to that of normal cells, makes asparagine depletion an effective method of treatment due to the cells' unusual dependency on circulating serum asparagine as a necessary nutrition for growth. A correlation between L-asparaginase efficacy and asparagine synthetase protein levels in a number of human ovarian cell lines has been observed. As mentioned above, this result confirmed similar observations in human leukemia cell lines. Hence asparagine synthetase might be used as a biomarker in ovarian cancer screening and potential treatment.