Aryl hydrocarbon Receptor Recombinant Rabbit Monoclonal Antibody [JM34-10] (ET1703-11)

UNIPROT #

P35869

PROTEIN NAME

Aryl hydrocarbon Receptor

SYNONYMS

Ah receptor antibody;AhR antibody;AHR_HUMAN antibody;Aromatic hydrocarbon receptor antibody;Aryl hydrocarbon receptor antibody;Aryl hydrocarbon receptor precursor antibody;bHLHe76 antibody;Class E basic helix loop helix protein 76 antibody;Class E basic helix-loop-helix protein 76 antibody;HGNC:348 antibody

TISSUE SPECIFICITY

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors.

POST-TRANSLATIONAL MODIFICATION

Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation. The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. AHR binds several exogenous ligands such as natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.