Lane 1: human lung tissue lysate
Lane 2: human liver tissue lysate
Recombinant Rabbit monoclonal primary
ARG1 Recombinant Rabbit Monoclonal Antibody [SY09-06] (ET1605-8)
Synthetic peptide within human arg1 aa 20-60.
Human lung tissue lysate, human liver tissue lysate.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
arg1 antibody; ARGI1_HUMAN antibody; Arginase-1 antibody; Liver-type arginase antibody; Type I arginase antibody
Belongs to the arginase family.
Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea. The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.
Liang, Ruichao et al.
Macrophage Polarization in Response to Varying Pore Sizes of 3D Polyurethane Scaffolds. | Journal of Biomedical Nanotechnology