ARF1 Rabbit Polyclonal Antibody (0807-7)

UNIPROT #

P84077

PROTEIN NAME

ARF1

SYNONYMS

ADP Ribosylation Factor 1 antibody;ADP-ribosylation factor 1 antibody;ARF 1 antibody;ARF1 antibody;ARF1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. Arf family.

POST-TRANSLATIONAL MODIFICATION

Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.

SUBCELLULAR LOCATION

Cell junction, Cytoplasm, Golgi apparatus, Membrane, Synapse, Synaptosome

FUNCTION

GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.