Aquaporin 4 Recombinant Antibody [PSH06-38] - Guinea pig IgG2 (Chimeric) (HA601461)

UNIPROT #

P55088

PROTEIN NAME

Aquaporin 4

SYNONYMS

AQP 4 antibody;AQP-4 antibody;AQP4 antibody;AQP4_HUMAN antibody;Aquaporin type 4 antibody;Aquaporin-4 antibody;Aquaporin4 antibody;HMIWC 2 antibody;HMIWC2 antibody;Mercurial insensitive water channel antibody;Mercurial-insensitive water channel antibody;MGC22454 antibody;MIWC antibody;WCH 4 antibody;WCH4 antibody

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane, Endosome membrane, Cell membrane, sarcolemma, Cell projection.

FUNCTION

Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. AQP4 shows the largest presence in the cerebellum and spinal cord grey matter. In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. In addition, this channel is commonly found facilitating water movement near cerebrospinal fluid and vasculature. Aquaporin-4 was first identified in 1986. It was the first evidence of the existence of water transport channels. The method that was used to discover the existence of the transport channels was through knockout experiments. With this technique they were able to show the significant role of AQP4 in CNS injuries and brain water imbalances. In 1994 the channel was successfully cloned and initially named Mercury-Insensitive Water Channel.