UNIPROT #

P02656

PROTEIN NAME

APOC3

SYNONYMS

APOC3 antibody; APO C3 antibody; Apo CIII antibody; Apo-CIII antibody; APOC 3 antibody; ApoC III antibody; ApoC-III antibody; APOC3 antibody; APOC3_HUMAN antibody; ApoCIII antibody; Apolipoprotein C III antibody; Apolipoprotein C-III antibody; Apolipoprotein C3 antibody; ApolipoproteinCIII antibody; MGC150353 antibody

SEQUENCE SIMILARITIES

Belongs to the apolipoprotein C3 family.

TISSUE SPECIFICITY

Liver.

POST-TRANSLATIONAL MODIFICATION

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.