Applications
-
WB
-
IHC-P
-
FC
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
APOC3 Rabbit Polyclonal Antibody (ER1802-47)
Immunogen
Recombinant protein within human apoc3 aa 2-99.
Host
Rabbit
Positive Control
Human liver tissue, HepG2.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
11 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:2000
-
IHC-P
-
1:50-1:200
-
FC
-
1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
APOC3
SYNONYMS
APOC3 antibody; APO C3 antibody; Apo CIII antibody; Apo-CIII antibody; APOC 3 antibody; ApoC III antibody; ApoC-III antibody; APOC3 antibody; APOC3_HUMAN antibody; ApoCIII antibody; Apolipoprotein C III antibody; Apolipoprotein C-III antibody; Apolipoprotein C3 antibody; ApolipoproteinCIII antibody; MGC150353 antibody
SEQUENCE SIMILARITIES
Belongs to the apolipoprotein C3 family.
TISSUE SPECIFICITY
Liver.
POST-TRANSLATIONAL MODIFICATION
The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.