Apo-H Recombinant Rabbit Monoclonal Antibody [JE37-02] (HA721649)

UNIPROT #

P02749

PROTEIN NAME

Apo-H

SYNONYMS

Activated protein C binding protein antibody;Activated protein C-binding protein antibody;Anticardiolipin cofactor antibody;APC inhibitor antibody;Apo-H antibody;APOH antibody;APOH_HUMAN antibody;apolipoprotein H (beta-2-glycoprotein I) antibody;Apolipoprotein H antibody;B2G1 antibody;B2GP1 antibody;B2GPI antibody;Beta 2 glycoprotein I antibody;Beta 2 glycoprotein I precursor antibody;Beta(2)GPI antibody;Beta-2-glycoprotein 1 antibody;Beta-2-glycoprotein I antibody;BG antibody;Glycoprotein 1, beta-2 antibody;Glycoprotein I, beta-2 antibody;OTTMUSP00000003033 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure.[6] Within the structure of Apo-H is a stretch of positively charged amino acids (protein sequence positions 282-287), Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding (see image on right). β2-GP1 has a complex involvement in agglutination. It appears to alter adenosine diphosphate (ADP)-mediated agglutination of platelets. Normally, β2-GP1 assumes an anticoagulation activity in serum (by inhibiting coagulation factors); however, changes in blood factors can result in a reversal of that activity. Although previously referred to as apolipoprotein H, it is not present in appreciable quantities in the lipoprotein fractions, so ApoH is therefore thought to be a misnomer.