APLP2 Recombinant Rabbit Monoclonal Antibody [JE54-62] (ET7110-78)

UNIPROT #

Q06481

PROTEIN NAME

APLP2

SYNONYMS

amyloid beta (A4) precursor like protein 2 antibody;Amyloid like protein 2 antibody;Amyloid precursor protein homolog HSD 2 antibody;amyloid precursor protein homolog HSD2 antibody;Amyloid protein homolog antibody;Amyloid-like protein 2 antibody;APLP-2 antibody;Aplp2 antibody;APLP2_HUMAN antibody;APPH antibody;APPL2 antibody;CDEBP antibody;CDEI box binding protein antibody;CDEI box-binding protein antibody

SEQUENCE SIMILARITIES

Belongs to the APP family.

TISSUE SPECIFICITY

Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.

POST-TRANSLATIONAL MODIFICATION

The BPTI/Kunitz inhibitor domain is O-glycosylated.

SUBCELLULAR LOCATION

Nucleus, cell membrane.

FUNCTION

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.