APC Recombinant Rabbit Monoclonal Antibody [SC61-03] (ET1610-80)

UNIPROT #

P25054

PROTEIN NAME

APC

SYNONYMS

Adenomatous Polyposis Coli antibody;Adenomatous polyposis coli protein antibody;Apc antibody;APC_HUMAN antibody;CC1 antibody;Deleted in polyposis 2.5 antibody;DP2 antibody;DP2.5 antibody;DP3 antibody;FAP antibody;FPC antibody;GS antibody;Protein APC antibody

SEQUENCE SIMILARITIES

Belongs to the adenomatous polyposis coli (APC) family.

TISSUE SPECIFICITY

Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver. Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues. Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by GSK3B.; Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.

SUBCELLULAR LOCATION

Cytoplasm, Cell junction, Cell membrane.

FUNCTION

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer. APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, how the cell polarizes and the morphogenesis of the 3D structures, or whether a cell moves within or away from tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein (see: Wnt signaling pathway). Regulation of beta-catenin prevents genes that stimulate cell division from being turned on too often and prevents cell overgrowth.