Antithrombin III / ATIII Recombinant Rabbit Monoclonal Antibody [PSH12-13] (HA723429)

UNIPROT #

P01008

PROTEIN NAME

Antithrombin III / ATIII

SYNONYMS

ANT3_HUMAN antibody;Antithrombin antibody;Antithrombin III antibody;Antithrombin-III antibody;AntithrombinIII antibody;AT 3 antibody;AT III antibody;AT3 antibody;AT3D antibody;ATIII antibody;Heparin cofactor I antibody;MGC22579 antibody;Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody;Serine cysteine proteinase inhibitor clade C member 1 antibody;Serine proteinase inhibitor clade C member 1 antibody;Serpin C1 antibody;Serpin family C member 1 antibody;Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody;SERPINC1 antibody;THPH7 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space.

FUNCTION

The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).