Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody [JM71-34] (ET1705-6)
Catalog# ET1705-6
Rabbit Monoclonal to Angiopoietin 2
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WB
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IHC-P
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FC
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Human
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Mouse
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Rat
Positive control:
Lane 1: TF-1 cell lysate
Lane 2: human liver tissue lysate
Lane 3: human placenta tissue lysate
Lane 4: mouse liver tissue lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody [JM71-34] (ET1705-6)
Immunogen
Synthetic peptide within human angiopoietin 2 aa 351-400 / 496.
Host
Rabbit
Positive Control
TF-1 cell lysate, human liver tissue lysate, human placenta tissue lysate, mouse liver tissue lysate, human colon carcinoma tissue, human placenta tissue, mouse liver tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM71-34
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:50-1:200
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FC
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1μg/mL
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 57 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Angiopoietin 2
SYNONYMS
AGPT 2 antibody;Agpt2 antibody;ANG 2 antibody;ANG-2 antibody;ANG2 antibody;Angiopoietin 2a antibody;Angiopoietin 2B antibody;Angiopoietin-2 antibody;Angiopoietin2 antibody;ANGP2_HUMAN antibody;ANGPT 2 antibody;Angpt2 antibody;Tie2 ligand antibody
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling. This antibody may have cross-recognition with Angiopoietin 1.
CITATIONS
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Xia, L., Liu, X., Mao, W., Guo, Y., Huang, J., Hu, Y., Jin, L., Liu, X., Fu, H., Du, Y., & Shou, Q.
Panax notoginseng saponins normalises tumour blood vessels by inhibiting EphA2 gene expression to modulate the tumour microenvironment of breast cancer
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WB
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Mouse
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Citation
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Saikosaponin-d regulates angiogenesis in idiopathic pulmonary fibrosis through angiopoietin/Tie-2 pathway
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WB
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IHC
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Mouse
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Citation
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Li, H., Song, D., Liu, Q., Li, L., Sun, X., Guo, J., Li, D., & Li, P.
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation
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WB
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Mouse
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Citation
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Refractory kaposiform lymphangiomatosis relieved by splenectomy
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IHC
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Human
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Citation
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Ma, Y., Yao, J., Zhou, S., Mi, Y., Tan, X., & Zhang, C.
Enhancing effect of FSH on follicular development through yolk formation and deposition in the low-yield laying chickens
