AMPK alpha 2 Mouse Monoclonal Antibody [A6A10] (HA600078)
Catalog# HA600078
Mouse Monoclonal to AMPK alpha 2
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: Hela cell lysate
Lane 2: Jurkat cell lysate
Lane 3: NIH/3T3 cell lysate
Specifications
Product Type
Mouse monoclonal primary
Product Name
AMPK alpha 2 Mouse Monoclonal Antibody [A6A10] (HA600078)
Immunogen
Recombinant protein within human ampk alpha 2 aa 231-430.
Host
Mouse
Positive Control
Hela cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-12 cell lysates, NIH/3T3, human kidney tissue, mouse brain tissue, rat kidney tissue, PC-12.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A6A10
RRID
APPLICATION DILUTION
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WB
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1:500
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IF-Cell
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1:50
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2ug/ul
Purification
Protein G affinity purified.
Molecular Weight
Predicted band size: 62 kDa
Isotype
IgG1
TARGET
UNIPROT #
PROTEIN NAME
AMPK alpha 2
SYNONYMS
5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody;AAPK2_HUMAN antibody;ACACA kinase antibody;Acetyl CoA carboxylase kinase antibody;Acetyl-CoA carboxylase kinase antibody;AMPK alpha 2 chain antibody;AMPK subunit alpha-2 antibody;AMPK2 antibody;AMPKa2 antibody;AMPKalpha2 antibody;HMGCR kinase antibody;Hydroxymethylglutaryl CoA reductase kinase antibody;Hydroxymethylglutaryl-CoA reductase kinase antibody;PRKAA antibody;PRKAA2 antibody;Protein kinase AMP activated alpha 2 catalytic subunit antibody;Protein kinase AMP activated catalytic subunit alpha 2 antibody
SUBCELLULAR LOCATION
Nucleus, Cytoplasm.
FUNCTION
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
CITATIONS
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Mi Ai,et al
Hepatoprotective efficacy and interventional mechanism of panaxanediol saponins component in high-fat diet-induced NAFLD mice
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WB
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Citation
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