AMPK alpha 1 Mouse Monoclonal Antibody [B1-E10] (M1409-1)

UNIPROT #

Q13131

PROTEIN NAME

AMPK alpha 1

SYNONYMS

5 AMP activated protein kinase alpha 1catalytic subunit antibody;5 AMP activated protein kinase catalytic alpha 1 chain antibody;5' AMP activated protein kinase catalytic subunit alpha 1 antibody;5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody;AAPK1 antibody;AAPK1_HUMAN antibody;ACACA kinase antibody;acetyl CoA carboxylase kinase antibody;AI194361 antibody;AI450832 antibody;AL024255 antibody;AMP -activate kinase alpha 1 subunit antibody;AMP-activated protein kinase, catalytic, alpha -1 antibody;AMPK 1 antibody;AMPK alpha 1 antibody;AMPK alpha 1 chain antibody;AMPK antibody;AMPK subunit alpha-1 antibody;AMPK1 antibody;AMPKa1 antibody;AMPKalpha1 antibody;C130083N04Rik antibody;cb116 antibody;EC 2.7.11.1 antibody;HMG CoA reductase kinase antibody;HMGCR kinase antibody;hormone sensitive lipase kinase antibody;Hydroxymethylglutaryl CoA reductase kinase antibody;im:7154392 antibody;kinase AMPK alpha1 antibody;MGC33776 antibody;MGC57364 antibody;OTTHUMP00000161795 antibody;OTTHUMP00000161796 antibody;PRKAA 1 antibody;PRKAA1 antibody;Protein kinase AMP activated alpha 1 catalytic subunit antibody;SNF1-like protein AMPK antibody;SNF1A antibody;Tau protein kinase PRKAA1 antibody;wu:fa94c10 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated.; Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also it acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. It may regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also AMPK phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.