Mouse monoclonal primary
AMPK alpha 1 Mouse Monoclonal Antibody [B1-E10] (M1409-1)
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AMPK alpha 1
5 AMP activated protein kinase alpha 1catalytic subunit antibody; 5 AMP activated protein kinase catalytic alpha 1 chain antibody; 5' AMP activated protein kinase catalytic subunit alpha 1 antibody; 5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody; AAPK1 antibody; AAPK1_HUMAN antibody; ACACA kinase antibody; acetyl CoA carboxylase kinase antibody; AI194361 antibody; AI450832 antibody; AL024255 antibody; AMP -activate kinase alpha 1 subunit antibody; AMP-activated protein kinase, catalytic, alpha -1 antibody; AMPK 1 antibody; AMPK alpha 1 antibody; AMPK alpha 1 chain antibody; AMPK antibody; AMPK subunit alpha-1 antibody; AMPK1 antibody; AMPKa1 antibody; AMPKalpha1 antibody; C130083N04Rik antibody; cb116 antibody; EC 188.8.131.52 antibody; HMG CoA reductase kinase antibody; HMGCR kinase antibody; hormone sensitive lipase kinase antibody; Hydroxymethylglutaryl CoA reductase kinase antibody; im:7154392 antibody; kinase AMPK alpha1 antibody; MGC33776 antibody; MGC57364 antibody; OTTHUMP00000161795 antibody; OTTHUMP00000161796 antibody; PRKAA 1 antibody; PRKAA1 antibody; Protein kinase AMP activated alpha 1 catalytic subunit antibody; SNF1-like protein AMPK antibody; SNF1A antibody; Tau protein kinase PRKAA1 antibody; wu:fa94c10 antibody
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Ubiquitinated.; Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. Dephosphorylated by PPM1A and PPM1B.
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also it acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. It may regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also AMPK phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.