AMPK alpha 1/2 Recombinant Rabbit Monoclonal Antibody [PSH08-86] (HA723038)

UNIPROT #

Q13131

PROTEIN NAME

AMPK alpha 1/2

SYNONYMS

5 AMP activated protein kinase alpha 1catalytic subunit antibody;5 AMP activated protein kinase catalytic alpha 1 chain antibody;5' AMP activated protein kinase catalytic subunit alpha 1 antibody;5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody;AAPK1 antibody;AAPK1_HUMAN antibody;ACACA kinase antibody;acetyl CoA carboxylase kinase antibody;AI194361 antibody;AI450832 antibody;AL024255 antibody;AMP -activate kinase alpha 1 subunit antibody;AMP-activate kinase alpha 1 subunit antibody;AMP-activated protein kinase, catalytic, alpha -1 antibody;AMPK 1 antibody;AMPK alpha 1 antibody;AMPK alpha 1 chain antibody;AMPK antibody;AMPK subunit alpha 1 antibody;AMPK subunit alpha-1 antibody;AMPK1 antibody;AMPKa1 antibody;AMPKalpha1 antibody;C130083N04Rik antibody;cb116 antibody;EC 2.7.11.1 antibody;HMG CoA reductase kinase antibody;HMGCR kinase antibody;hormone sensitive lipase kinase antibody;Hydroxymethylglutaryl CoA reductase kinase antibody;im:7154392 antibody;kinase AMPK alpha1 antibody;MGC33776 antibody;MGC57364 antibody;OTTHUMP00000161795 antibody;OTTHUMP00000161796 antibody;PRKAA 1 antibody;PRKAA1 antibody;Protein kinase AMP activated alpha 1 catalytic subunit antibody;SNF1-like protein AMPK antibody;SNF1A antibody;Tau protein kinase PRKAA1 antibody;wu:fa94c10 antibody;5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody;AAPK2_HUMAN antibody;Acetyl-CoA carboxylase kinase antibody;AMPK alpha 2 chain antibody;AMPK subunit alpha-2 antibody;AMPK2 antibody;AMPKa2 antibody;AMPKalpha2 antibody;Hydroxymethylglutaryl-CoA reductase kinase antibody;PRKAA antibody;PRKAA2 antibody;Protein kinase AMP activated alpha 2 catalytic subunit antibody;Protein kinase AMP activated catalytic subunit alpha 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. 5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.