AMACR Recombinant Antibody [PSH13-54] - Mouse IgG1 (Chimeric) (HA601602)

UNIPROT #

Q9UHK6

PROTEIN NAME

AMACR

SYNONYMS

2 arylpropionyl CoA epimerase antibody;2 methylacyl CoA racemase antibody;2-methylacyl-CoA racemase antibody;Alpha methylacyl CoA racemase antibody;Alpha methylacyl Coenzyme A racemase antibody;Alpha methylacyl-CoA racemase deficiency, included antibody;Alpha-methylacyl-CoA racemase antibody;Amacr antibody;AMACR deficiency, included antibody;AMACR_HUMAN antibody;CBAS4 antibody;Da1-8 antibody;EC 5.1.99.4 antibody;Macr1 antibody;Methylacyl CoA racemase alpha antibody;RACE antibody;RM antibody;P504S antibody

SUBCELLULAR LOCATION

Peroxisome, Mitochondrion.

FUNCTION

α-Methylacyl-CoA racemase (AMACR, EC 5.1.99.4) is an enzyme that in humans is encoded by the AMACR gene. In mammalian cells, the enzyme is responsible for converting (2R)-methylacyl-CoA esters to their (2S)-methylacyl-CoA epimers and known substrates, including coenzyme A esters of pristanic acid (mostly derived from phytanic acid, a 3-methyl branched-chain fatty acid that is abundant in the diet) and bile acids derived from cholesterol. This transformation is required in order to degrade (2R)-methylacyl-CoA esters by β-oxidation, which process requires the (2S)-epimer. The enzyme is known to be localised in peroxisomes and mitochondria, both of which are known to β-oxidize 2-methylacyl-CoA esters.