AMACR Rabbit Polyclonal Antibody (ER1706-60)

UNIPROT #

Q9UHK6

PROTEIN NAME

AMACR

SYNONYMS

2 arylpropionyl CoA epimerase antibody;2 methylacyl CoA racemase antibody;2-methylacyl-CoA racemase antibody;Alpha methylacyl CoA racemase antibody;Alpha methylacyl Coenzyme A racemase antibody;Alpha methylacyl-CoA racemase deficiency, included antibody;Alpha-methylacyl-CoA racemase antibody;Amacr antibody;AMACR deficiency, included antibody;AMACR_HUMAN antibody;CBAS4 antibody;Da1-8 antibody;EC 5.1.99.4 antibody;Macr1 antibody;Methylacyl CoA racemase alpha antibody;RACE antibody;RM antibody

SEQUENCE SIMILARITIES

Belongs to the CoA-transferase III family.

SUBCELLULAR LOCATION

Mitochondrion. Peroxisome.

FUNCTION

P504S, also known as AMACR (α-methylacyl-CoA racemase), 2-methylacyl-CoA racemase or RACE, is an enzyme belonging to the caiB/baiF CoA-transferase family. Localizing to the peroxisome and mitochondrion, P504S plays a role in the metabolism of branched-chain fatty acids and bile acid intermediates. More specifically, P504S catalyzes the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers which can then be degraded by peroxisomal β-oxidation. Mutations in the gene encoding P504S can lead to AMACR deficiency, a disease characterized by increased concentrations of pristanic acid that is associated with adult onset sensory motor neuropathy, and/or CBAS4 (congenital bile acid synthesis defect type 4), a disorder characterized by intrahepatic cholestasis, absence of cholic acid from bile, neonatal jaundice and bile duct deficiency. In addition, P504S is overexpressed in prostate cancer and is believed to be functionally important for prostate cancer cell growth.