alpha Actinin Rabbit Polyclonal Antibody (ER1803-60)

UNIPROT #

P12814

PROTEIN NAME

alpha Actinin

SYNONYMS

actinin 1 smooth muscle antibody;Actinin alpha 1 antibody;actinin, alpha 1 antibody;ACTN 1 antibody;Actn1 antibody;ACTN1_HUMAN antibody;Alpha Actinin 1 antibody;Alpha actinin cytoskeletal isoform antibody;Alpha-actinin cytoskeletal isoform antibody;Alpha-actinin-1 antibody;BDPLT15 antibody;F actin cross linking protein antibody;F-actin cross-linking protein antibody;FLJ40884 antibody;FLJ54432 antibody;Non muscle alpha actinin 1 antibody;Non-muscle alpha-actinin-1 antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-actinin family.

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cell projection, Cytoplasm, Plasma membrane. Cytoskeleton.

FUNCTION

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.