Lane 1: Hela
Lane 2: PC-12
Lane 3: NIH-3T3
Lane 4: Rat liver tissue
Lane 5: A431
Lane 6: HepG2
Recombinant Rabbit monoclonal primary
alpha Actinin 4 Recombinant Rabbit Monoclonal Antibody [JU20-23] (ET1706-05)
Hela, PC-12, NIH-3T3, rar liver tissue lysate, A431, HepG2, A549, LOVO, human colon cancer tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
alpha Actinin 4
actinin 4 antibody; Actinin alpha 4 antibody; actinin4 antibody; ACTN 4 antibody; ACTN4 antibody; ACTN4_HUMAN antibody; Alpha-actinin-4 antibody; DKFZp686K23158 antibody; F actin cross linking protein antibody; F-actin cross-linking protein antibody; Focal segmental glomerulosclerosis 1 antibody; FSGS 1 antibody; FSGS antibody; FSGS1 antibody; Non muscle alpha actinin 4 antibody; Non-muscle alpha-actinin 4 antibody
Belongs to the alpha-actinin family.
Cell junction. Cytoplasm. Nucleus.
The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure. are actually sensitive to the Profilin proteins in these foods.