Alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody [JF0980] (ET1702-30)

UNIPROT #

P35609

PROTEIN NAME

Alpha Actinin 2

SYNONYMS

Actin binding protein antibody;Actinin alpha 2 antibody;ACTN 2 antibody;ACTN2 antibody;ACTN2_HUMAN antibody;Alpha actinin 2 antibody;Alpha actinin skeletal muscle antibody;Alpha actinin skeletal muscle isoform 2 antibody;Alpha-actinin skeletal muscle isoform 2 antibody;Alpha-actinin-2 antibody;CMD1AA antibody;F actin cross linking protein antibody;F-actin cross-linking protein antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-actinin family.

TISSUE SPECIFICITY

Expressed in both skeletal and cardiac muscle.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by FBXL22, leading to proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.