Alpha 1 Acid Glycoprotein Rabbit Polyclonal Antibody (ER1802-27)

UNIPROT #

P02763

PROTEIN NAME

Alpha 1 Acid Glycoprotein

SYNONYMS

A1AG1_HUMAN antibody;AGP 1 antibody;AGP A antibody;AGP antibody;AGP1 antibody;Alpha 1 acid glycoprotein antibody;Alpha-1-acid glycoprotein 1 antibody;alpha-1-AGP antibody;Epididymis secretory sperm binding protein Li 153w antibody;glycoprotein, alpha-1-acid, of serum antibody;HEL S 153w antibody;OMD 1 antibody;ORM antibody;ORM1 antibody;Orosomucoid 1 antibody;Orosomucoid-1 antibody

SEQUENCE SIMILARITIES

Belongs to the calycin superfamily. Lipocalin family.

TISSUE SPECIFICITY

Expressed by the liver and secreted in plasma.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

AGP (α1-acid glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.