Applications
-
WB
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Alkaline Phosphatase(For 4 isoform) Rabbit Polyclonal Antibody (0806-3)
Immunogen
Synthetic peptide within human alkaline phosphatase aa 314-363 / 535.
Host
Rabbit
Positive Control
Hela
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Immunogen affinity purified
MOLECULAR WEIGHT
58 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:100-1:5000
TARGET
UNIPROT #
PROTEIN NAME
Alkaline Phosphatase(For 4 isoform)
SYNONYMS
Alkaline phosphatase antibody; Alkaline phosphatase placental antibody; Alkaline phosphatase placental type antibody; Alkaline phosphatase Regan isozyme antibody; ALP antibody; Alp1 antibody; ALPP antibody; FLJ61142 antibody; Germ-cell alkaline phosphatase antibody; nagao isozyme antibody; OTTHUMP00000164354 antibody; PALP antibody; Placental alkaline phosphatase 1 antibody; placental heat-stable alkaline phosphatase antibody; placental type antibody; PLAP antibody; PLAP-1 antibody; PLAP1 antibody; PPB1_HUMAN antibody
SEQUENCE SIMILARITIES
Belongs to the alkaline phosphatase family.
TISSUE SPECIFICITY
Detected in placenta (at protein level).
SUBCELLULAR LOCATION
Cell membrane or Lipid-anchor, GPI-anchor
FUNCTION
Alkaline phosphatase (ALP) removes phosphate groups from the 5' end of DNA and RNA, and from proteins. Most mammals have 4 different isozymes: placental, placental like, intestinal and non tissue specific (found in liver, kidney and bone). Tissues with particularly high concentrations of ALP include the liver, bile ducts, placenta, and bone. Placental ALP is highly polymorphic, there are at least three common alleles. Damaged or diseased tissue releases enzymes into the blood, so serum ALP measurements can be abnormal in many conditions, including bone disease and liver disease.