Alkaline Phosphatase(For 4 isoform) Rabbit Polyclonal Antibody (0806-3)

UNIPROT #

P05187

PROTEIN NAME

Alkaline Phosphatase(For 4 isoform)

SYNONYMS

Alkaline phosphatase antibody;Alkaline phosphatase placental antibody;Alkaline phosphatase placental type antibody;Alkaline phosphatase Regan isozyme antibody;ALP antibody;Alp1 antibody;ALPP antibody;FLJ61142 antibody;Germ-cell alkaline phosphatase antibody;nagao isozyme antibody;OTTHUMP00000164354 antibody;PALP antibody;Placental alkaline phosphatase 1 antibody;placental heat-stable alkaline phosphatase antibody;placental type antibody;PLAP antibody;PLAP-1 antibody;PLAP1 antibody;PPB1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the alkaline phosphatase family.

TISSUE SPECIFICITY

Detected in placenta (at protein level).

SUBCELLULAR LOCATION

Cell membrane or Lipid-anchor, GPI-anchor

FUNCTION

Alkaline phosphatase (ALP) removes phosphate groups from the 5' end of DNA and RNA, and from proteins. Most mammals have 4 different isozymes: placental, placental like, intestinal and non tissue specific (found in liver, kidney and bone). Tissues with particularly high concentrations of ALP include the liver, bile ducts, placenta, and bone. Placental ALP is highly polymorphic, there are at least three common alleles. Damaged or diseased tissue releases enzymes into the blood, so serum ALP measurements can be abnormal in many conditions, including bone disease and liver disease.