Lane 1: Hela cell lysate
Lane 2: SH-SY5Y cell lysate
Recombinant Rabbit monoclonal primary
ALIX Recombinant Rabbit Monoclonal Antibody [JM85-31] (ET1705-74)
Hela cell lysate, SH-SY5Y cell lysate, rat stomach tissue, human colon carcinoma tissue, human prostate tissue, Jurkat.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
AIP1 antibody; ALG 2 interacting protein 1 antibody; ALG-2-interacting protein 1 antibody; ALG2 interacting protein X antibody; Alix antibody; Apoptosis linked gene 2 interacting protein X antibody; Dopamine receptor interacting protein 4 antibody; DRIP4 antibody; Hp95 antibody; KIAA1375 antibody; MGC17003 antibody; PDC6I_HUMAN antibody; PDCD6 interacting protein antibody; PDCD6-interacting protein antibody; PDCD6IP antibody; Programmed cell death 6 interacting protein antibody; Programmed cell death 6-interacting protein antibody
May be phosphorylated on tyrosine residues by activated PDGFRB.
Centrosome, extracellular exosome, cytosol, melanosome, tight junction, midbody ring.
ALG-2-interacting protein (Alix), also designated programmed cell death 6-interacting protein (PDCD6-interacting protein), is a cytoplasmic protein. Alix interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. Additionally, Alix interacts with the endosomal sorting complexes required for transport (ESCRT) proteins (Tsg101 and CHMP4) and can associate with HIV-1. The endophilins (SH3P4, SH3P8 and SH3P13), enzymes that change curvature of the membrane that are required for early and late steps of coated vesicle formation, also bind to Alix. Alix is involved in the concentration and sorting of cargo proteins of the multivesicular body for incorporation into vesicles.