Lane 1: SH-SY5Y cell lysate
Lane 2: human liver tissue lysate
Lane 3: mouse liver tissue lysate
Lane 4: mouse kidney tissue lysate
Rabbit polyclonal primary
Aldolase B Rabbit Polyclonal Antibody (ER1901-42)
Recombinant protein within human aldolase b aa 1-189 / 364.
SH-SY5Y lysate, human liver tissue lysate, mouse liver tissue lysate, mouse kidney tissue lysate, rat kidney tissue, human liver tissue, human kidney tissue, mouse small intestine tissue, SH-SY5Y.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
ALDB antibody; ALDO B antibody; ALDO2 antibody; ALDOB antibody; ALDOB_HUMAN antibody; Aldolase 2 antibody; Aldolase B antibody; Aldolase B fructose bisphosphate antibody; Aldolase2 antibody; AldolaseB antibody; EC 220.127.116.11 antibody; Fructose bisphosphate aldolase B antibody; Fructose-bisphosphate aldolase B antibody; Liver type aldolase antibody; Liver-type aldolase antibody; MS1077 antibody
Belongs to the class I fructose-bisphosphate aldolase family.
Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 18.104.22.168), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP. In humans, aldolase B is encoded by the ALDOB gene located on chromosome 9. The gene is 14,500 base pairs long and contains 9 exons. Defects in this gene have been identified as the cause of hereditary fructose intolerance (HFI).