Aldolase Recombinant Rabbit Monoclonal Antibody [JM54-19] (ET1705-91)

UNIPROT #

P04075

PROTEIN NAME

Aldolase

SYNONYMS

ALDA antibody;Aldo1 antibody;ALDOA antibody;ALDOA_HUMAN antibody;Aldolase 1 antibody;Aldolase A antibody;Aldolase A fructose bisphosphatase antibody;Aldolase A fructose bisphosphate antibody;Aldolase, fructose-bisphosphate A antibody;Epididymis secretory sperm binding protein Li 87p antibody;FRUCTOALDOLASE A antibody;Fructose 1 6 bisphosphate triosephosphate lyase antibody;Fructose bisphosphate aldolase A antibody;Fructose bisphosphate aldolase antibody;FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A antibody;Fructose-bisphosphate aldolase A antibody;Fructose-bisphosphate aldolase A Muscle-type antibody;GSD12 antibody;HEL S 87p antibody;Lung cancer antigen NY LU 1 antibody;Lung cancer antigen NY-LU-1 antibody;MGC10942 antibody;MGC17716 antibody;MGC17767 antibody;Muscle type aldolase antibody;Muscle-type aldolase antibody;RNALDOG5 antibody

SEQUENCE SIMILARITIES

Belongs to the class I fructose-bisphosphate aldolase family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Fructose 1,6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate. Fructose 1,6-bisphosphate aldolase exists as three forms: the muscle-specific Aldolase A; the liver-specific Aldolase B; and the brain-specific Aldolase C. Aldolase A, B and C arose from a common ancestral gene from which Aldo-lase B first diverged. Aldolase A is one of the most highly-conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon, and has been implicated in hereditary fructose intolerance disease. Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells.