ALDH3A1 Recombinant Rabbit Monoclonal Antibody [PD00-73] (HA721201)

UNIPROT #

P30838

PROTEIN NAME

ALDH3A1

SYNONYMS

Acetaldehyde dehydrogenase 3 antibody;AHD 4 antibody;AHD C antibody;AHD4 antibody;AHDC antibody;AL3A1_HUMAN antibody;Aldehyde dehydrogenase 3 antibody;Aldehyde dehydrogenase 3 family member A1 antibody;Aldehyde dehydrogenase 3A1 antibody;Aldehyde dehydrogenase antibody;Aldehyde dehydrogenase class 3 antibody;Aldehyde dehydrogenase dimeric NADP preferring antibody;Aldehyde dehydrogenase family 3 member A1 antibody;Aldehyde dehydrogenase family 3 subfamily A1 antibody;Aldehyde dehydrogenase family 3, subfamily A, member 1 antibody;Aldehyde dehydrogenase isozyme 3 antibody;Aldehyde dehydrogenase type III antibody;ALDH 3 antibody;ALDH 3A1 antibody;ALDH III antibody;ALDH, stomach type antibody;ALDH3 A1 antibody;ALDH3 antibody;ALDH3A 1 antibody;Aldh3a1 antibody;ALDHIII antibody;dimeric NADP-preferring antibody;MGC10406 antibody;Stomach aldehyde dehydrogenase antibody;Tumor associated aldehyde dehydrogenase tumor ALDH antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).