AIM2 Rabbit Polyclonal Antibody (HA500270)

UNIPROT #

O14862

PROTEIN NAME

AIM2

SYNONYMS

Absent in melanoma 2 antibody;AIM 2 antibody;Aim2 antibody;AIM2_HUMAN antibody;Interferon-inducible protein AIM2 antibody;OTTHUMP00000035296 antibody;PYHIN4 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. In absence of dsDNA pyrin and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the pyrin domain for homotypic downstream signaling interactions with PYCARD.