AGL/Alpha-glucosidase Recombinant Rabbit Monoclonal Antibody [PSH04-56] (HA722155)

UNIPROT #

P35573

PROTEIN NAME

AGL/Alpha-glucosidase

SYNONYMS

1110061O17Rik antibody;4-1 antibody;4-glucantransferase antibody;6-glucosidase antibody;9430004C13Rik antibody;9630046L06Rik antibody;AGL antibody;AI850929 antibody;Amylo 1 6 glucosidase 4 alpha glucanotransferase antibody;Amylo-1 antibody;Amylo-alpha-1 antibody;C77197 antibody;Dextrin 6-alpha-D-glucosidase antibody;GDE antibody;GDE_HUMAN antibody;Glycogen debrancher antibody;Glycogen debranching enzyme antibody;Glycogen storage disease type III antibody;Oligo-1 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The glycogen debranching enzyme, in humans, is the protein encoded by the gene AGL. This enzyme is essential for the breakdown of glycogen, which serves as a store of glucose in the body. It has separate glucosyltransferase and glucosidase activities. Together with phosphorylases, the enzyme mobilize glucose reserves from glycogen deposits in the muscles and liver. This constitutes a major source of energy reserves in most organisms. Glycogen breakdown is highly regulated in the body, especially in the liver, by various hormones including insulin and glucagon, to maintain a homeostatic balance of blood-glucose levels. When glycogen breakdown is compromised by mutations in the glycogen debranching enzyme, metabolic diseases such as Glycogen storage disease type III can result. The two steps of glycogen breakdown, glucosyltransferase and glucosidase, are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in E. coli and other bacteria, complicating nomenclature. Proteins that catalyze both functions are referred to as glycogen debranching enzymes (GDEs). When glucosyltransferase and glucosidase are catalyzed by distinct enzymes, glycogen debranching enzyme usually refers to the glucosidase enzyme. In some literature, an enzyme capable only of glucosidase is referred to as a debranching enzyme.