Adiponectin Recombinant Rabbit Monoclonal Antibody [JE65-49] (HA721064)

UNIPROT #

Q60994

PROTEIN NAME

Adiponectin

SYNONYMS

30 kDa adipocyte complement related protein antibody;30 kDa adipocyte complement-related protein antibody;ACDC antibody;Acrp 30 antibody;ACRP30 antibody;ADIPO_HUMAN antibody;Adipocyte antibody;Adipocyte C1q and collagen domain containing protein antibody;Adipocyte complement related 30 kDa protein antibody;Adipocyte complement related protein of 30 kDa antibody;Adipocyte complement-related 30 kDa protein antibody;adipocyte-specific secretory protein antibody;Adiponectin antibody;Adiponectin precursor antibody;adiponectin, C1Q and collagen domain containing antibody;Adipoq antibody;Adipose most abundant gene transcript 1 antibody;Adipose most abundant gene transcript 1 protein antibody;Adipose specific collagen like factor antibody;ADIPQTL1 antibody;ADPN antibody;APM 1 antibody;apM-1 antibody;APM1 antibody;C1q and collagen domain-containing protein antibody;GBP 28 antibody;GBP28 antibody;Gelatin binding protein antibody;Gelatin binding protein 28 antibody;gelatin-binding protein 28 antibody;Gelatin-binding protein antibody;OTTHUMP00000210047 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels as well as fatty acid breakdown. In humans it is encoded by the ADIPOQ gene and it is produced in primarily in adipose tissue, but also in muscle, and even in the brain. Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. Transgenic mice with increased adiponectin show reduced adipocyte differentiation and increased energy expenditure associated with mitochondrial uncoupling. Adiponectin is secreted into the bloodstream where it accounts for approximately 0.01% of all plasma protein at around 5-10 μg/mL (mg/L). Adiponectin automatically self-associates into larger structures. Initially, three adiponectin molecules bind together to form a homotrimer. Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin; adiponectin and leptin can act synergistically. Adiponectin promoted synaptic and memory function in the brain. Humans with lower levels of adiponectin have reduced cognitive function.